Method for stimulating the immune system

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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514 8, A61K 39395, A61K 3800

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056058853

ABSTRACT:
The present invention includes methods and compositions for affecting the immune system in animals and humans. The methods and compositions include the administration of prolactin agonists to an immunosuppressed animal or human thereby stimulating the immune system. In addition, the present invention includes a vaccine adjuvant comprising the administration of a prolactin agonist with the vaccine.

REFERENCES:
patent: 4837202 (1989-02-01), Edwards, III
Arruda et al The Chemical Abstract, vol. 106, p. 90, 1987 Abst. No. 61505x.
Kiess et al, The Chemical Abstract, vol. 99, p. 102 1983, abst. No. 82789u.
Nagy, et al., "Immunomodulation by Bromocriptine", Immunopharmacology, 6:231-243 (1983).
Palestine, et al., "Bromocriptine and Low Dose Cyclosporine in the Treatment of Experimental Autoimmune Uveitis in the Rat", J. Clin. Invest., 79:1078-1081 (1987).
McCallum, et al., "Metoclopramide Stimulated Prolactin Secretion in Man", Jce of M, 42:1148-1152 (1976).
Hiestand, et al., "Prolactin as a modulator of lymphocyte responsivesness provides a possible mechanism of action for cyclosporine", Proc. Nat Acadmey of Science, 83:2599-2603 (1986).
Millard, et al., "Cysteamine Induced Depletion of Both Immunological and Biological Prolactin Activity in the Anterior Pituitary and Blood of the Rat", Endocrinology, 113:2161-2167 (1983).
Yamauchi, et al., "effect of Metoclopramide on rat Prolactin Secretin In Vivo", Life Sceinces, 20:1581-1583 (1977).
Bernton, et al., "Antibody to Mouse Prolactin Inhibits Murine Lymphocyte Responses to T-Cell Growth Factors (TCGF)", presented at the 11th Inter. Res. Congress & 24th Nat. 1. Reticuloendotheial Society, Oct. 17-21, 1987.
Bernton, et al., "Inhibition of Macrophage In Vivo Activation by Pharmacologic Blockade of Prolactin Release", Leukocytes and Host Defense, pp. 213-219 (1986).
Mancini, et al., "Effect of Sulpiride on Serum Prolactin Levels in Humans", J. Clin. Endoc. Metal., 48:181-183 (1976).
Connell, et al., "Effect of Low-Dose Dopamine Infusion on Basal and Stimulated TSH and Prolactin Concentrations, in Man", Clin. Endoc, 23:185-192 (1985).
Russell, et al., "Prolactin Receptors on Human Lymphocytes and Their Modulation by Cyclosporine", Biochem. Biophys. Res. Comm., 121:899-906 (1984).
Russell, et al., "Prolactin Receptors on Rat Lymphoid Tissues and on a Human T-and B-Lymphocytes: Antagonism of Prolactin Binding by Cyclosporine", Prolactin, Basic and Clinical Correlates, pp. 375-384 (1985).
Gahl, et al., "Blunted Prolactin Response to Thyrotropin-Releasing Hormone Stimulation in Cystinotic Children Receiving Cysteamine", J. Clin. Endocr. Metal., 60:793-796 (1985).
Bernton, "Prolactin and Immune Host Defenses", PNEI Perspectives, vol. 2, No. 1, 1989, pp. 21-29.
Hartman, et al., "Inhibition of Lymphocyte Proliferation by Anti-bodies to Prolactin", The FASEB Journal vol. 3, pp. 2194-2202 (Aug. 1989).
Dave, et al., "Prolactin binding a capacity, prostaglandin systhesis and fluidity of murine hepatic membranes are modified during pregnancy and lactation", J. Endocr., pp. 99-106.
Russell, et al., "Prolactin-dependent Mitogenesis in Nb 2 Node Lymphoma Cells: Effects of Immuno-Suppressive Cyclopeptides", J. of Immunology, vol. 138, pp. 276-284, (Jan. 1, 1987).
Boutin, et al., "Cloning an Expression of the Rat Prolactin Receptor a Number of the Growth Hormone/Prolactin Receptor Gene Family", Cell Press, vol. 53, pp. 69-77, (Apr. 1988).
Boutin, et al., "Long Form of Prolactin Receptor In Human Hepatoma and Breast Cancer Cell", Molecular Endocr. pp. 1455-1461 (1989).
Bryant, et al., "Cysteamine Produces Dose-Related Bidirectional Immunomondulatory Effects in Mice", Journal of Pharm. and Exper. Therap., vol. 249, No. 2, pp. 424-429 (1989).
Millard, et al., "Cysteamine-induced depletion of somatostatin and prolactin", Federation Proc. 44:pp. 2546-2550 (1985).
Bryant, et al., "Immunsuppression Effects of Chronic Morphine Treatment of Rats", Life Sciences, vol. 41 pp. 1731-1738.
Huseby, et al., "Ectopic Pituitary Grafts in Mice: Hormone Levels, Effects on Fertility, and the Development of Adenomyosis Ulterv, Prolactinomas, and Mannary Carcinomas", Endocrinology, 116:1440-1448 (1985).
Bernton, et al., "Suppression of Macrophase Activation and T-Lymphocyte Function in Hypoprolactinemic Mice", Science vol. 4, pp. 401-404 (Jan. 1988).
Hellhammer, et al., "Neurobiological Approaches to Human Disease", Library of Congress pp. 289-300 (1988).
Bernton, et al., "Pharmologic Manipulation of Pituitary Prolactin Secretion Modifies Lymphocyte Function in Mice".
Bernton, et al., "Suppression of Prolactin by Drugs: An IATrogenic Cause of Immunosuppression".
Jaroff, Time "Stop That Germ", pp. 56-64, May 25, 1988.
Cooke et al., "Human Prolactin: DCNA Structural Analysis and Evolutionary Comparison", The Journal of Biological Chemistry, vol . 256, No. 8, pp. 4007-4016 (Apr. 25, 1981).
Nicoll et al., "Structural Features of Prolactins and Growth Hormones that can be Related to Their Biological Properties", Endocrin Reviews, vol. 7 No. 2, pp. 169-203 (1986).
Cunningham et al., "Engineering Human Prolactin to Bind to the Human Growth Receptor," Science Reports, vol. 247, pp. 1461-1464 (Mar. 23, 1990).
Cunningham et al., "Zinc Mediation of the Binding of Human Growth Hormone to the Human Prolactin Receptor," Science Reports, vol. 250, pp. 1709-1712 (Dec. 21, 1990).
Rozakis-Adcock et al., "Mutational Analysis of the Ligand-Binding Domain of the Prolactin Receptor", The Journal of Biological Chemistry, vol. 266, No. 25, pp. 16472-16477 (Sep. 5, 1991).
Paris et al., "Bacterial Production and Purification of Recombinant Human Prolactin", Biotecnol. Appl. Biochem., vol. 12, No. 4, pp. 436-449 (1990).

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