Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ether doai
Patent
1987-10-09
1992-05-19
Waddell, Frederick E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ether doai
424 7838, A61K 3174
Patent
active
051147084
ABSTRACT:
The present invention relates to biologically-active copolymers and to compounds that can be safely used to cause the thymus of an animal or human to increase in size, thereby replenishing the T-lymphocyte population. When injected into an animal or human with an antigen, certain of the biologically-active copolymers cause immunosuppression to the antigen.
When injected into poultry, certain of the biologically-active copolymers modulate immune responsiveness. The biologically active copolymers are also useful as growth promoters for animals. Compounds within the biologically-active copolymers of the present invention are effective tumoricidal agents. At low concentration, certain of the biologically-active copolymers can cause dedifferentiated cells to differentiate.
The biologically-active copolymer of the present invention is a safe and non-toxic formulation that can effectively be administered to animals or humans. The biologically-active copolymer can be mixed in an oil and water emulsion and administered to an animal or human by injection or by oral administration.
REFERENCES:
patent: 2861887 (1958-11-01), Colby et al.
Hunter et al., "The Adjuvant Activity of Nonionic Block Polymer Surfactants," The Journal of Immunology, 127:3, pp. 1244-1250, 1981.
Schmolka, Irving R., "A Review of Block Polymer Surfactants," Journal of the American Oil Chemists' Society, vol. 54, No. 3, pp. 110-116, 1977.
Atkinson et al., "Induction of Suppressor Cells by Reverse Block Copolymers," Federal Proceedings, vol. 44, No. 7596, p. 7594, 1985.
Hunter et al., "The Adjuvant Activity of Nonionic Block Polymer Surfactants," The Journal of Immunology, 133:6, pp. 3167-3175, 1984.
Patent Cooperation Treaty International Search Report, PCT/US86/01315, filed on Jun. 18, 1986.
Hunter Robert L.
Ragland William L.
Emory University
Waddell Frederick E.
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