Method for sterilizing products with gamma radiation

Chemical apparatus and process disinfecting – deodorizing – preser – Process disinfecting – preserving – deodorizing – or sterilizing – Using direct contact with electrical or electromagnetic...

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422 44, 250432R, 20415821, 435 2, 426240, A61L 208, A01N 102

Patent

active

053624424

ABSTRACT:
A method for sterilizing products to remove biological contaminants such as viruses, bacteria, yeasts, molds, mycoplasmas and parasites is disclosed. The method involves providing the product in a form that contains less than 20% solids and subsequently irradiating the product with gamma irradiation over an extended period of time. Generally the product is irradiated for a period of not less than 10 hours. The extended irradiation time in conjunction with the low level of solids in the product substantially reduces the damage to the product. The method is useful in sterilizing sensitive materials such as blood and blood components.

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Wyatt, D. E.; Keathley, J. D.; Williams, C. M.; and Broce, B. Is There Life After Irradiation? Part 1, BioPharm Jun. 1993, pp. 34-39.
Wyatt, D. E., Keathley, J. D.; Williams, C. M.; and Broce, B. Is There Life After Irradiation? Part 2, BioPharm Jul.-Aug. 1993, pp. 46-52.
Leitman, S. F. Use of Blood Cell Irradiation in the Prevention of Post transfusion Graft-vs-Host Disease, Transfus. Sci. 1989; 10:219-232.
Martindale's Extra Pharmacopoecia, Glucose p. 1265; prior art.
The Merck Index, Eleventh Edition Glucose pp. 4353-4354, prior art.

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