Method for sterilizing liquid chromatography resins highly resis

Details Method for sterilizing liquid chromatography resins highly resis Method for sterilizing liquid chromatography resins highly resis

1996-06-07

1997-10-14

Therkorn, Ernest G.

Liquid purification or separation

Processes

Liquid/liquid solvent or colloidal extraction or diffusing...

210656, 210759, 210764, 2101982, 422 28, 422 30, B01D 1508

Patent

active

056768370

ABSTRACT:
A method for sterilizing liquid chromatography resins that are highly resistant to oxidation by strongly oxidizing agents and a sterilization solution for use therein. In a preferred embodiment, the invention comprises contacting an oxidant-resistant chromatographic resin with an aqueous solution of peracetic acid and up to 40% ethanol. In particular, where the solution is to be used to sterilize a positively charged ion-exchange resin, the solution preferably additionally includes an acetate buffer of a sufficient ionic strength to prevent adsorption of the peracetic acid ions on the resin.

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Flemming, "Microbial Growth on Ion Exchangers," Wat. Res., vol. 21, No. 7, pp. 745-756 (1987).
Leaper, "Synergistic killing of spores of Bacillus subtilis by peracetic acid and alcohol," Journal of Food Technology, 19:355-360 (1984).

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