Method for stabilizing Tumor Necrosis Factor and a stable aqueou

Details Method for stabilizing Tumor Necrosis Factor and a stable aqueou Method for stabilizing Tumor Necrosis Factor and a stable aqueou

1983-08-19

1984-07-03

Rosen, Sam

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

424 95, A61K 3516, A61K 3512

Patent

active

044579160

ABSTRACT:
A method for stabilizing Tumor Necrosis Factor (TNF), which comprises adding a stabilizing agent selected from a nonionic surfactant, at least one substance selected from the group consisting of D-glucose, D-galactose, D-xylose, D-glucuronic acid, a salt of D-glucuronic acid, trehalose, a dextran and a hydroxyethyl starch, and mixtures thereof to an aqueous solution or powder containing TNF, and a stable aqueous solution or powder which contains TNF and an effective amount of such a stabilizing agent selected from a nonionic surfactant, a specific sugar or sugar-related compound and mixtures thereof. The aqueous solution or powder containing TNF can be stored for a prolonged period of time without losing its activity, and is stable on freezing, thawing, lyophilization, heat-treatment or the like.

REFERENCES:
patent: 4309418 (1982-01-01), Green
Ruff et al., J. Immunol., vol. 125, No. 4 (1980), pp. 1671-1677.
Gifford et al., Chem. Abst., vol. 93 (1980), p. 147,902Z.

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