Method for stabilizing tissue plasminogen activator and a stable

Details Method for stabilizing tissue plasminogen activator and a stable Method for stabilizing tissue plasminogen activator and a stable

1984-04-23

1985-11-12

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

260112R, 260117, 424 95, 424105, 435 68, 435188, 435212, 435215, 435216, 435219, 435240, C12N 950, A61K 31715, A61K 3512, A61K 3548

Patent

active

045527601

ABSTRACT:
A method for stabilizing a tissue plasminogen activator which involves adding to an aqueous solution or powder containing a tissue plasminogen activator an effective amount of a purified gelatin is disclosed. A stable aqueous solution or powder which contains a tissue plasminogen activator and an effective amount of a purified gelatin is also disclosed. The method and composition eliminate the problem of adsorption of tissue plasminogen activator to various laboratory equipment, and also prevent the conversion of the single-chain tissue plasminogen activator into a double-chain tissue plasminogen activator.

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patent: 4495285 (1985-01-01), Shimizu et al.
Biochimica et Biophysica Acta, 717 (1982), 327-336, Sueishi et al.

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