Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Attached to lymphokine – cytokine – or other secreted growth...
Patent
1996-12-11
1998-12-01
Hollinden, Gary E.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
Attached to lymphokine, cytokine, or other secreted growth...
424 145, 424 149, 424 165, 424 169, 424 173, 424 153, 5303913, 534 10, A61K 5100, C07F 500, C07K 1600
Patent
active
058433961
ABSTRACT:
A stabilized composition comprising an organic compound labeled with a .beta.-emitting radionuclide and a stabilizing effective amount of a non-radiolabeled stabilizing compound selected from the group consisting of (i) heteroaryls having at least one nitrogen atom, said heteroaryl being substituted with at least one sulfur-containing moiety selected from the group consisting of thiol and thiocarbonyl provided that the nitrogen atoms are not adjacent to one another; (ii) aryls being substituted with at least one nitrogen-containing moiety selected from the group consisting of amino and isothiocyanate and with at least one sulfur-containing moiety selected from the group consisting of sulfonamide, sulfonate, and thiol; and (iii) alkylamines having at least one to four carbon atoms, said alkylamine being substituted with at least one sulfur-containing moiety selected from the group consisting of thioacid and thiocarbonyl provided that when the sulfur-containing moiety is a thioacid then the aminoalkyl contains only one nitrogen atom.
REFERENCES:
patent: 4358434 (1982-11-01), Tzodikov et al.
patent: 4390517 (1983-06-01), O'Brien et al.
patent: 4411881 (1983-10-01), Tzodikov
patent: 4451451 (1984-05-01), Rimmer
patent: 4793987 (1988-12-01), Henderson et al.
patent: 5118499 (1992-06-01), Theodoropulos
patent: 5284644 (1994-02-01), Kruper, Jr. et al.
patent: 5393512 (1995-02-01), Vanderheyden et al.
patent: 5395608 (1995-03-01), Troutner et al.
patent: 5494654 (1996-02-01), Price et al.
patent: 5514363 (1996-05-01), Shochat et al.
Etlis, V. S. et al., Synthesis and Antiradiation Properties of Polymeric Dithiocarbamates, Khimiko-Farmatsevticheskii Zhurnal, 10, No. 4, pp. 452-453, Apr. 1976.
Barnes, J. H. et al., Synthesis and Radioprotective Effects of the Disodium Alkanebisdithiocarbamates of .omega.-aminoalkyldithiocarbamic Acids and Their N,N'-dimethyl Derivatives, Eur. J. Med. Chem.-Chimica Therapeutica, 10, No. 6, pp. 619-622, Nov.-Dec. 1975.
Sheppard, G., The Self-Decomposition of Radioactively Labelled Compounds, Atomic Energy Review, pp. 3-66, 1972 Without Month.
Liebster J. and Kopoldova J., The Radiation Chemistry of Amino Acids, Radiation Biology, pp. 157-226, 1964.
Nagai, K. et al., Apparatus For Base Sequence Determination in Nucleic Acids, Chemical Abstracts, 111:93463b, p. 388, 1989.
Gan Nadine Michele Loretta
Overmeyer Gary Thomas
Shaw Douglas Roger Dennistoun
Hartley Michael G.
Hollinden Gary E.
NEN Life Science Products, Inc.
LandOfFree
Method for stabilizing radiolabeled organic compounds by adding does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for stabilizing radiolabeled organic compounds by adding , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for stabilizing radiolabeled organic compounds by adding will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2393180