Method for stabilizing pranoprofen and stable liquid preparation

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514912, 514913, 514914, 514915, A61K 3144

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active

058563458

ABSTRACT:
A method for stabilizing pranoprofen, comprising placing an aqueous solution of pranoprofen in coexistence with an antioxidant, or placing an aqueous solution of pranoprofen under the conditions of limited supply of oxygen, and a stable aqueous preparation of pranoprofen, comprising pranoprofen and an antioxidant. According to the present invention, the decomposition of pranoprofen in an aqueous solution of pranoprofen is remarkably suppressed. In particular, pranoprofen becomes stable to light, thus permitting long-term preservation of an aqueous solution, specifically a liquid preparation, of pranoprofen.

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patent: 5693337 (1997-12-01), Suzuki et al.
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Chemical Abstracts, vol. 118, 1993 No. 118:66887f (Abstract of Reference AD).
Chemical Abstracts, vol. 105, 1986, No. 105: 158837z.

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