Method for stabilizing or causing regression of atherosclerosis

Details Method for stabilizing or causing regression of atherosclerosis Method for stabilizing or causing regression of atherosclerosis

1989-10-23

1991-10-29

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514114, 514423, A61K 3140, A61K 3166, A61K 3700

Patent

active

050616943

ABSTRACT:
A method is provided for slowing the progression of atherosclerosis in coronary arteries in hypertensive or normotensive patients and reducing or eliminating atherosclerotic lesions in such patients in a mammalian species by administering an ACE inhibitor, especially one containing a mercapto moiety, such as captopril or zofenopril.

REFERENCES:
patent: 4316906 (1982-02-01), Ondetti et al.
Overturf, M., et al., Atherosclerosis, 59:383-399, 1986.
Zorn, J., et al., "Prevention of Arteriosclerotic Lesions with Calcium Antagonists or Captopril in Different Rat Hypertension Models," J. Cardiovasc. Pharmacol., vol. 12 (Suppl 6), (1988).
Someya, N., et al., "Suppressive Effect of Captopril on Platelet Aggregation in Essential Hypertension," J. Cardiovasc. Pharmacol., 6:840-843 (1984).
Mizuno, K., et al., "The Effects of the Angiotensin I-Converting Enzyme Inhibitor, Captopril, on Serum Lipoperoxides Level and the Renin-Angiotensin-Aldosterone and Kallikrein-Kinin Systems in Hypertensive Patients," Nippon Naibunpi Gakkai Zasshi, Fef. 20, 1984.
Mizuno, K., et al., "Acute Effects of Captopril on Serum Lipid Peroxides Level in Hypertensive Patients," Tohoku J. Exp. Med., May, 1984, 143(1) pp. 127-128.
Cecil, Textbook of Medicine, 16 Ed., pp. 239-241.

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