Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Stablizing an enzyme by forming a mixture – an adduct or a...
Patent
1994-01-26
1995-08-15
Naff, David M.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Stablizing an enzyme by forming a mixture, an adduct or a...
435 71, 435174, 435192, 436518, 536103, 536124, C12N 996, C12N 908, C08B 3716, A61K 31735
Patent
active
054418798
ABSTRACT:
The antigenicity of a myeloperoxidase is stabilized by applying a solution of cyclodextrin to a myeloperoxidase and incubating the myeloperoxidase with the solution of cyclodextrin. The myeloperoxidase may be immobilized on an insoluble carrier prior to applying the solution of cyclodextrin. The stabilized myeloperoxidase can be stored for a long period of time, even at high temperature, and used as a reagent in an immunoassay.
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Sigma Chemie--Biochemicalien Organische Verbindingen voor Research en Diagnostica--1992--p. 692 "Myeloperoxidase"--Brussels.
Journal of Immunological Methods--Determination of anti-neutrophil cytoplasm antibodies (ANCA) specificity by immunofluorescence on chronic myelocytic leukemia cells--A. Chevailler et al, vol. 147, 1992, pp. 101-109, Amsterdam.
Izutsu et al, "Stabilization of .beta.-galactosidase . . . " Int. J. Pharm. 90:187-194 (1993).
Horiuchi Kazumi
Nishiki Nobuo
Naff David M.
Nissho Corporation
Prats Francisco C.
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