Method for stabilizing an immobilized fibrinolytic enzyme

Details Method for stabilizing an immobilized fibrinolytic enzyme Method for stabilizing an immobilized fibrinolytic enzyme

1985-11-18

1988-08-16

Naff, David M.

Chemistry: molecular biology and microbiology

Carrier-bound or immobilized enzyme or microbial cell;...

435176, 435178, 435180, 435188, C12N 1100, C12N 996

Patent

active

047644664

ABSTRACT:
A fibrinolytic enzyme immobilized on a carrier is stabilized by treating the surface of the carrier on which the enzyme is immobilized with a basic amino acid. The amino acid is preferably histidine, arginine or lysine. Carriers may be inorganic materials, natural polymeric materials or synthetic polymeric materials, in a variety of forms. Fibrinolytic enzymes immobilized include plasmin, brinase, urokinase, streptokinase and tissue plasminogen activator. The stabilized immobilized fibrinolytic enzyme maintains activity better during storage or sterilization.

REFERENCES:
patent: 3950223 (1976-04-01), Yugari et al.
patent: 4244943 (1981-01-01), Yamahira et al.
patent: 4246349 (1981-01-01), Chessing et al.
Chibata, I., Immobilized Enzymes, John Wiley & Sons, N.Y. 1978, pp. 22, 23, 26, 27, 134-143, 216 and 217.

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