Method for solution phase synthesis of oligonucleotides and pept

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Synthesis of peptides

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530300, 536 253, 536 2533, 536 2534, 536 231, C07K 100, C07K 300, C12H 1500

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active

060019662

ABSTRACT:
This invention discloses an improved method for the sequential solution phase synthesis of oligonucleotides and peptides. The method lends itself to automation and is ideally suited for large scale manufacture oligonucleotides with high efficiency.

REFERENCES:
patent: 2871225 (1959-01-01), Bortnick et al.
patent: 3137684 (1964-06-01), Bodanszky
patent: 5539082 (1996-07-01), Nielsen et al.
patent: 5580697 (1996-12-01), Keana et al.
patent: 5874532 (1998-02-01), Pieken et al.
Barton et al. (1970) J. Chem. Soc. (D) 939.
Beaucage and Iyer (1992) Tetrahedron 48:2223.
Bonora et al. (1993) Nucleic Acids Res. 21:1213.
Bonora (1987) Gazzetta Chimica Italiana 117:379.
Bonora et al. (1990) Nucleic Acids Res. 18:3155.
Bonora et al. (1991) Nucleosides & Nucleotides 10:269.
Bonora (1995) Applied Biochemistry and Biotechnology 54:3.
Bonora and Scremin (1992) Innovation Prespec. Solid Phase Synth. Collect. Paol, Int. Symp., 2nd, "Large Scale Synthesis of Oligonucleotides. The HELP Method: Results and Perspectives", pp. 355-358, published by Intercept, Andover, UK.
Carpino and El-Faham (1995) J. Am. Chem. Soc. 117:5401.
Carpino et al. (1990) J. Am. Chem. Soc. 112:9651.
colonna et al., (1991) Tetrahedron Lett. 32:3251.
Cookson et al. (1967) J. Chem. Soc.(C) 1905.
Cookson et al. (1971) Org. Syn. 51:121.
Gausepohl et al. (1990) Chemical Abstract, vol. 112, p. 674, col. 2, abstract No. 235812m.
Keanna et al. (1983) J. Org. Chem. 48:2654.
Matteucci and Caruthers (1981) J. Am. Chem. Soc. 103:3185.
Merrigield (1963) J. Am. Chem. Soc. 85:2149.
Mitchell et al. (1978) J. Org. Chem. 43:2845.
Ravikumar et al. (1995) Tetrahedron Lett. 36:6587.
Schaller et al. (1963) J. Am. Chem. Soc. 85:3821.
Scremin and Bonora (1993) Tetrahedron Lett. 34:4663.
Seliger and Schmidt (1987) Journal of Chromatography 397:141.
Sundram and Griffin (1995) J. Org. Chem. 60:1102.
Wright et al. (1993 ) Tetrahedron Lett. 34:3373.
Zaramella and Bonora (1995) Nucleosides & Nucleotides 14:809.
Zon and Geiser (1991) Anti-Cancer Drug Design 6:539.
Xie et al. BBRC 177(1):252-258, 1991.

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