Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Hormones – e.g. – prolactin – thymosin – growth factors – etc.
Patent
1991-12-20
1992-09-29
Schain, Howard E.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Hormones, e.g., prolactin, thymosin, growth factors, etc.
530397, 530403, 530420, 530410, 530324, C07K 312, C07K 1506
Patent
active
051515016
ABSTRACT:
The present invention relates to a process for solubilization and naturation of somatotropins utilizing a combination of sulfolane and an aqueous alkaline solution. By utilizing the process of the present invention, enhanced yields of end product result.
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patent: 4977248 (1990-12-01), Creighton
patent: 5064943 (1991-11-01), McCoy et al.
Sharma, Separation Science and Technology, 21(8), 701-726, 1986.
American Cyanamid Company
Jackson H. G.
Schain Howard E.
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