Method for solubilization and naturation of somatotropins utiliz

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Hormones – e.g. – prolactin – thymosin – growth factors – etc.

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Details

530397, 530403, 530420, 530410, 530324, C07K 312, C07K 1506

Patent

active

051515016

ABSTRACT:
The present invention relates to a process for solubilization and naturation of somatotropins utilizing a combination of sulfolane and an aqueous alkaline solution. By utilizing the process of the present invention, enhanced yields of end product result.

REFERENCES:
patent: 4511502 (1985-04-01), Builder et al.
patent: 4694073 (1987-09-01), Bentle et al.
patent: 4731440 (1988-03-01), Bentle et al.
patent: 4923967 (1990-05-01), Bobbitt et al.
patent: 4977248 (1990-12-01), Creighton
patent: 5064943 (1991-11-01), McCoy et al.
Sharma, Separation Science and Technology, 21(8), 701-726, 1986.

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