Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Hormones – e.g. – prolactin – thymosin – growth factors – etc.
Patent
1988-12-16
1991-11-12
Draper, Garnette D.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Hormones, e.g., prolactin, thymosin, growth factors, etc.
435 694, 530412, C07K 312, C07K 1506
Patent
active
050649434
ABSTRACT:
A method for solubilization and naturation of somatotropin using an aqueous alkaline solution results in lower dimer formation and eliminates denaturants and separate renaturation steps and agents.
REFERENCES:
patent: 4511503 (1985-04-01), Olson et al.
patent: 4652630 (1987-03-01), Bentle et al.
patent: 4677196 (1987-06-01), Rausch et al.
Sharma, S. K., 1986, Separation Science and Technology 21(8):701-726.
Frost Robert A.
McCoy Kevin M.
American Cyanamid Company
Draper Garnette D.
Furman Keith C.
Tsevdos Estelle J.
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