Method for solid phase peptide synthesis

Details Method for solid phase peptide synthesis Method for solid phase peptide synthesis

2011-05-10

2011-05-10

Tate, Christopher R. (Department: 1654)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Synthesis of peptides

C530S300000

Reexamination Certificate

active

07939629

ABSTRACT:
A novel method for synthesizing a Hirulog peptide is devised.

REFERENCES:
patent: 1 314 745 (2003-05-01), None
patent: WO 91/02750 (1991-07-01), None
International Search Report for PCT/EP2005/011226 mailed Dec. 16, 2005.
Okayama et al.,Anticoagulant peptides; synthesis, stability and antithrombin activity of hirudin C-terminal-related peptides and their disulfated analog, Chemical and Pharmaceutical Bulletin (Tokyo), vol. 44, No. 7, 1996, pp. 1344-1350, XP001207786.
Freund, E. et al “Solid-phase synthesis of a putative heptapeptide intermediate in vancomycin biosynthesis” Chem. Commun., 1999, 2509-2510.
Burgess & Lim: “Resin type can have important effects on solid phase asymmetric alkylation reactions” Chem. Commun., vol. 1997, 1997, pp. 785-786.
Giraud et al.: “A side-reaction in the SPPS of trp-containing peptides.” J. Peptide Sci., vol. 5, 1999, pp. 457-461.
Guillier et al.: “Linkers and cleavage strategies in solid-phase organic synthesis and combinatorial chemistry” Chem. Rev., vol. 100, 2000, pp. 2091-2157.

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