Method for sleep induction

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...

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514625, 514923, A61K 3116

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active

056123809

ABSTRACT:
Sleep may be induced by administration of fatty acid primary amides, including cis-9,10-octadecenoamide. Furthermore, sleep deprivation may be assayed by analyzing cerebrospinal fluid with respect to the presence of fatty acid primary amides, including cis-9,10-octadecenoamide. The presence of cis-9,10-octadecenoamide in cerebrospinal fluid is correlated with comparative sleep deprivation.

REFERENCES:
patent: 4729834 (1988-03-01), Itoh
patent: 4851431 (1989-07-01), Yehuda
patent: 5163982 (1992-11-01), de Andrade Bruuning
Arafat, et al., "Identification of Fatty Acid Amides in Human Plasma", Life Sciences, 45: 1679-1687 (1989).
Wakamutsu et al., "Isolation of Fatty Acid Amide as an Angiogenic Principle from Bovine Mesentery", Biochem. and Biophys. Research Comm., 168: 423-429 (1990).
Taranova, et al., "Lipid peroxidation of rat brain synaptosomes in sleep disturbance", abstract No. 105:169775, Fiziol. Zh. SSSR im. I.M. Sechenova vol. 72, No. 8, pp. 1065-1068 (1986).

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