Method for site-specific integration of nucleic acids and relate

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

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435 29, 435194, 435455, 435456, 435463, 435468, 435471, 530300, 530350, C07K 1405, C07K 1415, C07K 14155, C07K 1416, C12N 912, C12N 1587, C12Q 168, C12Q 102

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060108606

ABSTRACT:
Chimeric proteins are provided comprising a first domain that attaches said chimeric protein to a target nucleic acid, and a second domain that integrates donor nucleic acid into a target nucleic acid. Also provided are nucleic acid constructs, recombinant vectors encoding invention chimeric proteins, recombinant retroviruses, and related methods.

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