Method for simultaneously drying and granulating extract substan

Details Method for simultaneously drying and granulating extract substan Method for simultaneously drying and granulating extract substan

1986-09-29

1988-06-28

Lusignan, Michael R.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424475, 424101, 427 3, 427213, A61K 900, A61K 1500, A61K 2100, B05D 700

Patent

active

047538031

ABSTRACT:
The invention relates to a fluidized-bed method for simultaneously obtaining the dry matter from aqueous solutions of extract substances from deproteinized calves blood and producing granules which can be compressed to give solid medicament forms and contain at least 50% by weight of extract substances, relative to the total dry weight of the granules, a binder and pharmaceutically acceptable fillers and carriers, by spraying an aqueous solution of the extract substances and of the binder on to the fillers and carriers and granulating the mixed material at a defined water content in the fluidized bed. After drying, granules ready for compression are obtained, and they are used for producing solid medicament forms of high stability and constant quality.

REFERENCES:
patent: 3458622 (1969-07-01), Hill
patent: 4662880 (1987-05-01), Hamel et al.
Schnellen, Med. Welt, vol. 19, No. 3, p. 198, Jan. 1968:-"Uber die Behandlung schlecht heilender Ulzera mit Actihaemyl".
Sucket, H., Fuchs, P., Speiser, P.: Pharmaceutical Technology, Stuttgart, 1978, pp. 409-413.
Ritschel, W. A., The Tablet, Fundamental Principles and Practice of Tableting, Pelletizing and Drugging; Aulendorf in Wuertt., 1966, pp. 211-212, 213.

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