Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1998-06-19
2000-05-23
Brusca, John S.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
536 243, 536 2431, C12Q 168, C07H 2104
Patent
active
060664592
ABSTRACT:
A spectral imaging method for simultaneous detection of multiple fluorophores aimed at detecting and analyzing fluorescent in situ hybridizations employing numerous chromosome paints and/or loci specific probes each labeled with a different fluorophore or a combination of fluorophores for color karyotyping, and at multicolor chromosome banding, wherein each chromosome acquires a specifying banding pattern, which pattern is established using groups of chromosome fragments labeled with various fluorophore or combinations of fluorophores.
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Ried et al. Simultaneous visualization of seven different DNA probes by in situ hybridization using combinatorial fluorescence and digital imaging microscopy. Proc. Natl. Acad. Sci. vol. 89 pp. 1388-1392, 1992.
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Schrock et al. "Multicolor Spectral Karyotyping of Human Chromosomes", Science,273: 494-497, 1996.
Speicher et al, "Karyotyping Human Chromosomes by Combinatorial Multi-Fluor FISH", Nature Genetics, vol. 12, 1996.
Buckwald Robert A.
Cabib Dario
Garini Yuval
Ried Thomas
Soenksen Dirk G.
Applied Spectral Imaging Ltd.
Brusca John S.
Friedman Mark M.
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