Chemistry: analytical and immunological testing – Automated chemical analysis – With aspirator of claimed structure
Patent
1999-02-25
2000-11-28
Noland, Thomas P.
Chemistry: analytical and immunological testing
Automated chemical analysis
With aspirator of claimed structure
G01N 3022
Patent
active
061534374
ABSTRACT:
A cassette chemical immobilization and treatment method enables the performance of various complex chemistries with minimal human intervention, near-zero dead volume, and flow-through protocols pursuant to a predetermined instruction set encoded on a multiple-address chemical treatment cassette assembly. The cassette assembly comprises a plurality of analyte sample columns ("mini-columns"), having a high-pressure interface capability to permit direct insertion of the mini-column into a high-pressure solvent line for use as a support column for HPLC analysis. A sample loader loads analyte samples either singly or simultaneously into the multiple, addressable mini-columns without the need to load the sample funnel/column assembly into a separate reaction chamber. The inventive system reads the machine readable instruction code and performs chemistries on the analyte, including mixing solvents, reactants and buffers; detaching and shuttling the analyte back and forth; performing complex chemistries either on or off-column; solvation of powdered or lyophillized reagents; and performing in-line, on-board analysis. These protocols are performed automatically pursuant to instructions contained on a bar code, without having to remove the cassette or interface from the CTS, or otherwise require human intervention. The same chemistries may be performed on all sample mini-column addresses, or a separate completely independent set of protocols may be defined for each address, or for each block of addresses pursuant to the instructions contained in the machine readable code on the cassette.
REFERENCES:
patent: 3518164 (1970-06-01), Andelin et al.
patent: 3559454 (1971-02-01), Evans
patent: 3996017 (1976-12-01), Kaiser
patent: 4046634 (1977-09-01), Mercer
patent: 4096825 (1978-06-01), Golias et al.
patent: 4102179 (1978-07-01), Snell
patent: 4166720 (1979-09-01), Weber
patent: 4186607 (1980-02-01), Porter et al.
patent: 4285698 (1981-08-01), Otto et al.
patent: 4376391 (1983-03-01), Brunnee
patent: 4692308 (1987-09-01), Riley et al.
patent: 4915847 (1990-04-01), Dillon et al.
patent: 4929426 (1990-05-01), Bodai et al.
patent: 4932081 (1990-06-01), Burns
patent: 5045196 (1991-09-01), Fang
patent: 5084242 (1992-01-01), Sakuma et al.
patent: 5178832 (1993-01-01), Phillips et al.
patent: 5228988 (1993-07-01), Sanford et al.
patent: 5229074 (1993-07-01), Heath et al.
patent: 5236666 (1993-08-01), Hulette et al.
patent: 5358641 (1994-10-01), Sanford et al.
patent: 5374395 (1994-12-01), Robinson et al.
patent: 5439645 (1995-08-01), Saralegui et al.
patent: 5468643 (1995-11-01), Su et al.
patent: 5500071 (1996-03-01), Kaltenbach et al.
patent: 5529899 (1996-06-01), Wheelock et al.
patent: 5571410 (1996-11-01), Swedberg et al.
patent: 5578268 (1996-11-01), Champseix et al.
patent: 5580528 (1996-12-01), Demers
patent: 5589063 (1996-12-01), Sanford et al.
patent: 5602037 (1997-02-01), Ostgaard et al.
patent: 5645702 (1997-07-01), Witt et al.
patent: 5646046 (1997-07-01), Fischer et al.
patent: 5658413 (1997-08-01), Kaltenbach et al.
patent: 5697409 (1997-12-01), Bishop et al.
patent: 5762873 (1998-06-01), Fanning et al.
patent: 5800784 (1998-09-01), Horn
patent: 5814277 (1998-09-01), Bell et al.
patent: 5885530 (1999-03-01), Babson et al.
Patent Abstracts of Japan Grp P819, vol. 13, No. 37 Abs pub date Jan. 27, 1989 (63-235858) "Selection of LC Eluting Conditions and Minicolumn" Ishida et al.
Hewlett-Packard Product Brochure; The HP G1004A Protein Chemistry Station minimizes sample handling and sample loss in HPLC and sequencing analysis. (23) 5091-5168E 11/92) (4 pp.).
Hewlett-Packard Product Brochure: Increase lab productivity with the HP G005A Protein Sequencing System. (23-5091 5170E 11/92) (7 pp.).
Amersham Pharmacia Biotech AB
Noland Thomas P.
Protigal Stanley N.
Sabath Robert P.
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