Chemistry: analytical and immunological testing – Heterocyclic carbon compound – Hetero-o
Patent
1990-05-30
1993-12-14
Wax, Robert A.
Chemistry: analytical and immunological testing
Heterocyclic carbon compound
Hetero-o
436149, 250340, 250341, G01N 3348, G01N 2518
Patent
active
052702146
ABSTRACT:
The base pairs of a DNA structure are sequenced with the use of a scanning tunneling microscope (STM). The DNA structure is scanned by the STM probe tip, and, as it is being scanned, the DNA structure is separately subjected to a sequence of infrared radiation from four different sources, each source being selected to preferentially excite one of the four different bases in the DNA structure. Each particular base being scanned is subjected to such sequence of infrared radiation from the four different sources as that particular base is being scanned. The DNA structure as a whole is separately imaged for each subjection thereof to radiation from one only of each source.
REFERENCES:
patent: 4675283 (1987-06-01), Roninson
patent: 4706192 (1987-11-01), Nasu
patent: 4729947 (1988-03-01), Middendorf
patent: 4802101 (1989-01-01), Hara
patent: 4865968 (1989-12-01), Orgel
patent: 5003815 (1991-04-01), Martin et al.
Allinger et al., "Organic Chemistry", Worth Publishers, Inc., NY, NY, 1971.
Dunlap et al., Nature 342:204-206 (Nov. 1989).
Keller et al., PNAS, USA 86:5356-5360 (Jul. 1989).
J. Dawson and A. Sessler, "DNA Base Sequencer: Scanning Tunneling Microscope Plus Infrared Radiation," Lawrence Berkeley Laboratory Report LBL-27660, Aug. 1989, pp. 108-113.
Charles Petit, "Beyond the Cutting Edge," MOSAIC, vol. 20, No. 2, Summer 1989, pp. 24-35.
Thomas P. Beebe, Jr., "Direct Observation of Native DNA Structures with the Scanning Tunneling Microscope," Science, vol. 243, Jan. 20, 1989, pp. 370-372.
Dawson John
Sessler Andrew M.
Gaither Roger S.
McAndrews Isabelle R.
Moser William R.
The United States of America as represented by the United States
Wax Robert A.
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