Method for separation of enantiomeric isomers by simulated...

Details Method for separation of enantiomeric isomers by simulated... Method for separation of enantiomeric isomers by simulated...

2007-12-11

2007-12-11

Therkorn, Ernest G. (Department: 1723)

Liquid purification or separation

Processes

Liquid/liquid solvent or colloidal extraction or diffusing...

C210S656000, C210S659000, C210S198200, C210S502100

Reexamination Certificate

active

10943436

ABSTRACT:
The present invention provides a method having a high productivity for preparative separation by simulated moving bed chromatography. That is, in a filler for enantiomeric isomer separation by simulated moving bed chromatography, which has a porous carrier carrying a polysaccharide derivative thereon and has a TS coefficient in a range of 0.55 to 1.20, the TS coefficient being defined by the below-shown formula (I), and obtained by using an enantiomeric isomer separation column for simulated moving bed chromatography in which the filler is filled in a column tube by a slurry filling method:in-line-formulae description="In-line Formulae" end="lead"?TScoefficient=[Vc−[t(TS)−t(blank)]×FR]/[t(TS)−t(blank)]×FR,  (I)in-line-formulae description="In-line Formulae" end="tail"?whereinVc (cm3): a column volume;FR (ml/min.): a flow velocity;t(TS) (min.): an elution time for tetrakis(trimethylsilyl)silane (=TS); andt(blank) (min.): an elution time for TS in the state where the column is not connected.

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Machine translation of Onishi (Japan Publication No. 2001-296288).
Machine translation of Ogasawara (Japan Publication No. 07-330802).
European Patent Office Search Report dated Jun. 28, 2005 (3 pages).

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