Method for separation of diastereoisomeric 3-(3,4-dibenzyloxyphe

Details Method for separation of diastereoisomeric 3-(3,4-dibenzyloxyphe Method for separation of diastereoisomeric 3-(3,4-dibenzyloxyphe

1978-07-07

1981-01-20

Reamer, James H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

562402, C07C 5143

Patent

active

042464285

ABSTRACT:
A method for separation of diastereoisomeric 3-(3,4-dibenzyloxyphenyl)serine, which comprises reacting a mixture of the threo isomer and erythro isomer of 3-(3,4-dibenzyloxyphenyl)serine with a mineral acid and separating the mixture of the resulting mineral acid salts of the threo isomer and erythro isomer into each mineral acid salt by a conventional fractional crystallization utilizing the difference in solubility of the mineral acid salts, and optionally converting the separated mineral acid salt into a free isomer. Said 3-(3,4-dibenzyloxyphenyl)serine or a mineral acid salt thereof thus separated can give 3-(3,4-dihydroxyphenyl)serine which is a precursor of norepinephrine and which has activity in the circulatory system or psychotropic activities by removing the benzyl group therefrom.

REFERENCES:
patent: 3182079 (1965-05-01), Talsumi et al.
patent: 3723514 (1973-03-01), Hegedus et al.
patent: 3830836 (1974-08-01), Soichiro et al.
Bolhofer, J.A.C.S., vol. 76, pp. 1322-1326 (1954).

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