Method for separating plasma from blood and silanized glass fibr

Details Method for separating plasma from blood and silanized glass fibr Method for separating plasma from blood and silanized glass fibr

1987-03-04

1988-11-22

Richman, Barry S.

Chemistry: analytical and immunological testing

Clotting or clotting factor level tests

21050024, 21050026, 210508, 210509, 422 55, 422 56, 428391, 428392, 428401, 436170, 436178, 435 13, G01N 2178, G01N 3000, G01N 3386

Patent

active

047866039

ABSTRACT:
Hydrophilic glass fibers which have bonded to their surfaces a layer of silane molecules of the formula ##STR1## are useful for the separation of plasma from blood for haemostasiological testing. In the formula: the molecule is bonded at its end oxygen to a surface of a glass fibre; R.sub.1 is C.sub.2 -C.sub.6 alkylene; X is OH, C.sub.1 -C.sub.6 alkoxy, having n carbon atoms and up to (n-1) OH groups in which n is 1-6, or an amino acid or peptide residue; and each of R'.sub.3 and R".sub.3 is C.sub.1 -C.sub.6 alkyl, an oxygen bridge to the silicon atom of another silane molecule or an oxygen bridge to the glass surface. The fibres have an average diameter of from 0.2 to 5 microns and a density of 0.1 to 0.5 g/cm.sup.3.

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Larsson et al., High-Performance Liquid Affinity . . . ", Adv. Chromatography 21, 48-55 (1978) [Excerpt.].

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