Method for separating liquid compositions on the basis of molecu

Details Method for separating liquid compositions on the basis of molecu Method for separating liquid compositions on the basis of molecu

1986-02-10

1988-12-06

Fisher, Richard V.

Liquid purification or separation

Processes

Liquid/liquid solvent or colloidal extraction or diffusing...

2101952, 21032165, 210805, 210808, B01D 1300

Patent

active

047894822

ABSTRACT:
An ultrafiltration device comprising hollow fibers or thin channels through which ultrafiltration of blood plasma is effected is operated under conditions of tangential flow and low conversion. A recirculation stream of high molecular weight fraction of the liquid stream is fed to the device and a permeate stream from the device is recovered. The optimum module aspect ratio is designed and the corresponding maximum shear rate of incoming liquid is specified and controlled so as to provide maximum separation efficiency (selectivity and flux) allowing for separation between species of similar size or molecular weight. Shear rate is controlled by controlling the recirculation stream flow rate. The ratio of the transmembrane pressure at the channel outlet to the transmembrane pressure at the channel inlet resulting from the optimal design and operation is also specified.

REFERENCES:
patent: 3228877 (1966-01-01), Mahon
patent: 4350156 (1982-09-01), Malchesky et al.
patent: 4397747 (1983-08-01), Ikeda
patent: 4540492 (1985-09-01), Kessler
Shettigar et al., "Continuous Enrichment of Albumin in Relation to Globulins in Plasma", Artificial Organs, May 1982, pp. 163-168.
Gurland, H. J. et al., "Comparative Evaluation of Filters Used in Membrane Plasmapheresis" Nephron 36: pp. 173-182 (1984).

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