Method for separating and measuring the amount of polar compound

Details Method for separating and measuring the amount of polar compound Method for separating and measuring the amount of polar compound

1983-03-11

1986-05-20

Lacey, David L.

Chemistry: analytical and immunological testing

Heterocyclic carbon compound

Hetero-n

436111, 436128, 436131, 436161, 436178, G01N 118, G01N 3006, G01N 3348

Patent

active

045901660

ABSTRACT:
This invention relates to a novel method for separating and measuring the amount of polar compounds, such as pyridostigmine, acetylcholine, neostigmine, and edrophonium, and their metabolites in aqueous solutions. The method is used to determine the urinary excretion and plasma levels of polar compounds administered to animals.

REFERENCES:
Davison et al, Meth. and Find. Exptl. Clin. Pharmacol., vol. 2, No. 2, pp. 7-82 (1980).
Yakatan et al, J. of Chromatography, vol. 164, pp. 399-403 (1979).
De Ruyter et al, J. of Chromatagraphy, vol. 183, pp. 193-201 (1980).
Jsuda et al, J. of Chromat., 158 (1978) pp. 227-232.
De Ruyter et al, Chemical Abstracts, vol. 93, No. 93:142550y (1980).
Chan et al, Chemcial Abstracts, vol. 90, No. 90:132478e (1979).
Coper et al, Chemical Abstracts, vol. 81, No. 101497v (1974).
Yakatan et al, Chemical Abstracts, vol. 92, No. 92:121426b (1980).

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