Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1994-06-16
1999-01-05
Scheiner, Toni R.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 724, 435 722, 435375, 435378, 435383, 435394, 436543, G01N 33574, C12N 502, C12N 506
Patent
active
058561129
ABSTRACT:
A method for selectively inducing expression of biomarkers for urologic cancers, including prostate and bladder cancer, is disclosed. Tumor cells are cultured using a low shear rotational three-dimensional technique under conditions effective to induce said selective expression. The method is useful for diagnostic and therapeutic applications.
REFERENCES:
patent: 4495288 (1985-01-01), Jarvis, Jr. et al.
patent: 4559311 (1985-12-01), Stenman et al.
patent: 4582799 (1986-04-01), Jarvis, Jr.
patent: 4839046 (1989-06-01), Chandler
patent: 4988623 (1991-01-01), Schwarz et al.
patent: 4994374 (1991-02-01), Nishikawa et al.
patent: 5002890 (1991-03-01), Morrison
patent: 5023172 (1991-06-01), Djordjevic
patent: 5026650 (1991-06-01), Schwarz et al.
patent: 5085983 (1992-02-01), Scanlon
patent: 5104802 (1992-04-01), Rhodes et al.
patent: 5153118 (1992-10-01), Wright, Jr. et al.
patent: 5153131 (1992-10-01), Wolf et al.
patent: 5153132 (1992-10-01), Goodwin et al.
patent: 5153133 (1992-10-01), Schwarz et al.
patent: 5155034 (1992-10-01), Wolf et al.
patent: 5155035 (1992-10-01), Schwarz et al.
patent: 5162504 (1992-11-01), Horoszewicz
Donaldson, J. T., et al., Int. J. Cancer, 46, pp. 238-244, 1990.
Sacks, P. G., et al., J. Cancer Res. Clin. Oncol., 118, pp. 490-496, 1992.
Bauer, et al., "Techniques for studies on growth characteristics of human prostate cancer cells," Biotechnol Prog 8:494-500 (1992).
Berkvig, R. "Tumor Spheroids from Biopsy Specimens," in Spheroid culture in cancer research, CRC Press, Boca Raton, 41-56, (1992).
Biran, et al., "Growth of human mammary carcinoma cells from biopsy specimens in serum-free medium on extracellular matrix," Int J Cancer 38:345-354 (1986).
Morimitsu, et al., "Morphologic characteristics, proliferation and tumor marker expression of two human ovarian carcinoma cell lines in three-dimensional culture," Gynecol Oncol 48:155-164 (1993).
Acker, Carlsson, and Stalnacke, "Electro-Physiological Measurements in Cultured Cellular Spheroids," Acta. Path. Microbiol. Immunol. Scand., Sect. A, 91:151-160, 1983.
Carlsson and Brunk, "The Fine Structure of Three-Dimensional Colonies of Human Glioma Cells in Agarose Culture," Acta. Path. Microbiol. Scand., Sect. A, 85:183-192, 1977.
Carlsson and Nederman, "Tumor Spheroids as a Model in Studies of Drug Effects," In Spheroid Culture in Cancer Research, CRC Press, Boca Raton, pp. 199-212, 1992.
Carlsson, "Tumor Spheroids in Studies of Immunotherapy," In Spheroid Culture in Cancer Research, CRC Press, Boca Raton, pp. 277-300, 1992..
Prewett, Goodwin and Spaulding, "Three-Dimensional Modeling of T-24 Human Bladder Carcinoma Cell Line: A New Simulated Microgravity Culture Vessel," J. Tiss. Cult. Meth., 15:29-36, 1993.
Freyer, "Spheroids in Radiobiology Research," In Spheroid Culture in Cancer Research, CRC Press, Boca Raton, pp. 217-275, 1992.
Hoke, "Advanced Lab Bioreactors Extend Cell and Tissue Culture Capabilties," The Scientist pp. 17-18, Jul. 12, 1993.
Knuchel and Sutherland, "Cell Differentiation and Heterogeneity in Spheroid Culture," Spheroid Culture in Cancer Research, CRC Press, Boca Raton, pp. 159-170, 1992.
Marley et al., "Three-Dimensional In Vitro Culture of an Androgen-Refactory Prostate Cancer Cell Line Causes Alterations in Patterns of Biomarker Expressions," Proceedings of the American Association for Cancer Research, 38:544, Mar. 1997.
Marley et al., "DNA Content and F-Actin Expression Within Human Glioma Spheroids Cultured In Vitro," J. Cell Biol., 115:227a, 1991, Abstract No. 1320.
Meikle and Smith, "Epidermiology of Prostate Cancer," Urologic Clinics of North America, 17(4):709-718, Nov. 1990.
Nederman et al., "Demonstration of an Extracellular Matrix in Multicellular Tumor," Cancer Research, 44:3090-3097, Jul. 1984.
Nederman and Twentyman, "Spheroids for Studies of Drug Effects, " Recent Results in Cancer Research, 95:84-102, 1984.
Parent-Vaugeois et al., "Variavle Modulation of Expression of Two Superficial Human Bladder Tumor Associated Antigens by Spatial Configuration of Cell Populations" Proceedings of the American Association for Cancer Research, 30:355, Mar. 1989 Abtract No. 1410.
deVere et al., "Prognosis in Disseminated Prostate Cancer as Related to Tumor Ploidy and Differentiation," World J. Urol., 8:47-50, 1990.
Sutherland, "Cell and Environment Interactions in Tumor Microregions: The Multicell Spheroid Model," Science, 240:177-184, Apr. 1988.
Sutherland and Durand, "Growth and Cellular Characteristics of Multicell Spheroids," Recent Results in Cancer Research, 95:24-49, 1984.
Van Moorselaar et al., "Combined Effects of Tumor Necrosis Factor Alpha and Radiation in the Treatment of Renal Carcinoma Grown as Radia Spheroids," Anticancer Research, 10:1769-1774, 1990.
Veltri et al., "DNA/F-Actin Analysis of a Potential In Vitro Glioma Model," Proceedings of the American Association for Cancer Research, May 21, 1992, Abstract No. 251.
Olive and Banath, "Growth Fraction Measured in WiDr Human Colon Carcinoma Speroids and Xenografts Using Comet Assay," Proceedings of the American Association for Cancer Research, May 21, 1992, Abstract No. 252.
Veltri et al., "DNA Content and Tumor Biomarker Expression from a Novel Spheroidal In Vitro Prostatic Human Tumor Model," Proceedings of the American Association of Cancer Research Annual Meeting May 20, 1993 Orlando, Florida.
Marley, Gonda and Ingram, Human Glioma Spheroid Formation in the NASA-JSC Bioreactor, J. Cel Biol., 3:481a, 1990. Abstract No. 2697.
Sutherland and Carlsson, "Spheroids in Cancer Research," Cancer Research, 41:2980-2994, 1981.
Beckett, et al., "Monoclonal antibody PD-41 recognizes an antigen restricted to prostate adenocarcinomas," Cancer Res 51:1326-1333 (1991).
Cordon-Cardo, et al., "Immunopathologic analysis of human bladder cancer: characterization of two new antigens associated with low-grade superficial bladder tumors," Am J Pathol 140:375-385 (1992).
Diamond, et al., "Computerized image analysis of nuclear shape as a prognostic factor for prostatic cancer," The Prostate 3:321-332 (1982).
Fradet, et al., "Polymorphic expression of a human superficial bladder tumor antigen defined by mouse monoclonal antibodies," Proc Natl Acad Sci USA 84:7227-7231 (1987).
Fradet, Yves, "Markers of prognosis in superficial bladder cancer," Seminars in Urology X:28-38 (1992).
Gleason, D.F., "Prediction of prognosis for prostatic adenocarcinoma by combined histological grading and clinical staging," J Urology 111:58-64 (1974).
Gleason, D.F., "Histological grading of prostate carcinoma," In: Contemporary Issues in Surgical Pathology of the Prostate. D.G. Bostick (ed.), Churchill Livingstone, Edinburgh, pp. 83-93 (1990).
Kuhn, et al., "Expression of the c-erbB2 (HER-2
eu) oncoprotein in human prostatic carcinoma," J Urology 150:1427-1433 (1993).
Lineham, et al., "Metastatic models and molecular genetics of prostate cancer," J Natl Cancer Inst 84:914-915 (1992).
Lipford, et al., "Comparative study of monoclonal antibodies TURP-27 and HNK-1: their relationship to neural cell adhesion molecules and prostate tumor-associated antigens," Cancer Res 51:2296-2301 (1991).
Mueller-Klieser, W. "Multicellular spheroids: a review on cellular aggregates in cancer research," J Cancer Res Clin Oncol 113:101-122 (1987).
Partin, et al., "A comparison of nuclear morphometry and Gleason grade as a predictor of prognosis in stage A2 prostate cancer a critical analysis," J Urology 142:1254-1258 (1989).
Partin, et al., "Use of nuclear morphometry, Gleason histologic scoring, clinical stage, and age to predict disease-free survival among patients with prostate cancer," Cancer 70:161-168 (1992).
Peters, et al., "Prognostic significance of the nuclear DNA content in localized prostate adenocarcinoma," Anal Quant Cytol Histol 12:359-365 (1990).
Pressman, N.J., "Markovian an analysis of cervical cell images," J Histochem Cytochem 24:138-144 (1976).
Starling, et al., "Human prostate tissue antigens defined by murine monoclonal antibodies," Cancer Res. 46:367-374 (1986).
Stevenson, et al., "Flow Cytometry of Prostate Cancer: Relationship of DNA Content to Survival," Cance
Marley Garry M.
Veltri Robert W.
Scheiner Toni R.
Urocor Inc.
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