Method for selectively increasing the ratio of single major comp

Details Method for selectively increasing the ratio of single major comp Method for selectively increasing the ratio of single major comp

1986-05-19

1990-05-22

Warren, Charles F.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Using a micro-organism to make a protein or polypeptide

435 78, 435827, 435244, 435169, C12P 1956, C12P 2104, C12N 138

Patent

active

049277545

ABSTRACT:
The object of this invention is to provide a method for selectively increasing the ratio of the single T-A2 major components in the T-A2 complex. More particularly, the object of this invention is a process for obtaining teicoplanin A.sub.2 selectively enriched in any of its major components, T-A2-1, T-A2-2, T-A2-3, T-A2-4 and T-A2-5 which consists in adding to the culture medium of Actinoplanes teichomyceticus nov. sp. ATCC 31121 or a mutant thereof which produces T-A2 complex through the same metabolic pathway, a selectively effective amount of an appropriate precursor.

REFERENCES:
patent: 4239751 (1980-12-01), Coronelli

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