Method for selectively increasing the ratio of single major comp

Details Method for selectively increasing the ratio of single major comp Method for selectively increasing the ratio of single major comp

1997-12-18

1999-07-20

Marx, Irene

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Using a micro-organism to make a protein or polypeptide

435 74, 435 75, 435 76, 435127, 435244, 435169, C12P 2104, C12N 138

Patent

active

059255501

ABSTRACT:
The present invention relates to a method for selectively enhancing the production of factors A.sub.2 and/or A.sub.3 of antibiotic A/16686 either to isolate these single components or to enrich the complex in one or both the above components, which comprises adding an appropriate precursor of the desired antibiotic factor to an A/16686 producing culture during fermentation.

REFERENCES:
patent: 4427656 (1984-01-01), Cavalleri et al.
patent: 5108988 (1992-04-01), Ciabatti et al.
patent: 5491128 (1996-02-01), Ciabatti et al.
patent: 5539087 (1996-07-01), Restelli et al.
Ciabatti et al., The Journal of Antibiotics, vol. XLII No. 2, Feb., 1989, pp. 254-267.

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