Method for selectively controlling unwanted expression or functi

Details Method for selectively controlling unwanted expression or functi Method for selectively controlling unwanted expression or functi

1984-04-27

1988-07-12

Brown, J. R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 47, 514 51, A61K 3170, A61K 31665

Patent

active

047570555

ABSTRACT:
A process for selectively controlling or interfering with the effect or function of foreign nucleic acid in the presence of otherwise normal living cells which comprises determining the base sequence for said nucleic acid and binding the said nucleic acid with an appropriately prepared nonionic oligonucleoside alkyl or arylphosphonate analogue which is complementary to the indicated sequence of the foreign nucleic acid.

REFERENCES:
patent: 4469863 (1984-09-01), Ts'O et al.
patent: 4507433 (1985-03-01), Miller et al.
patent: 4511713 (1985-04-01), Miller et al.
Miller et al., "Interrelationship Among Aging, Cancer and Differentiation", Pullman et al. (eds), D. Reidel Publishing Co., 1985, pp. 207-219.
Smith et al., "Proc. Natl. Acad. Sci.", U.S.A., vol. 83, pp. 2787-2791, May 1986.
Agris et al., Biochemistry, in press, 1986.

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