Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1995-02-16
1996-06-18
Chan, Christina Y.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 17, A61K 3817, A61K 3822, C07K 14435
Patent
active
055277780
ABSTRACT:
A method for selectively opening abnormal brain tissue capillaries of a mammal in order to allow selective passage of both low and high molecular weight neuropharmaceutical agents into abnormal brain tissue. The method utilizes direct infusion of bradykinin or bradykinin analog into the carotid artery. The dose of bradykinin or bradykinin analog is maintained at levels which provide opening of abnormal brain tissue capillaries without opening normal brain capillaries. The method is useful for introducing a wide variety of neuropharmaceutical agents selectively to brain tumors and other abnormal brain tissue.
REFERENCES:
patent: 5112596 (1992-05-01), Malfroy-Carmine
Blasberg et al. "Regional Blood Flow, Capillary permeability and glucose utilization in two brain turion models: preliminary observations and pharmakinetic implications", Cancer Treatment Rep. 1981 2:3-12. Abstract.
Levin et al, "Heonistic Modeling of Drug Delivery to Malignant Brain Tumors", L. Pharmacokinetic. Biophasn 1980 83:257-96. Abstract.
Shibata et al, "(Ultrastructural) study of capillary permeability of lipsome-encapsulates cisplatin in are experimental rat Brain Tumor Model", Neurol Med Chir 1989, 29 (8):696-700. Abstract.
Watts, R. G. and Merchant, R. E. "Cerebaovascular Effects and Tumor Kinetics After a single Inbratumoral injection of human recomb, I1-2 . . . in a rat model of Glionia", Neurosurgery 1992, 31 (1) 89-98; discussion 98-99. Abstract.
Phillips et al. "Reduced Cerabral Glucose Metabolism and Increase Brain Capillary Permeability Follows High Dose Metabolism Chemotherapy: a positron emision tomographic study". Ann Neurol. 1987 21 (1) 59-63. Abstract.
Robinson P. L. et al. "Model for Drug Uptabe by Brain Tumors: Effects of Osmotic Treatment and of Diffosion in Brain". J. Cereb. Flow Metab. 1990, 10(2):153-156. Abstract.
Miyagami et al., "ACNU Delivery to maglignant cpeoia tissue by osmotic blood Brain Barrier Modification with Intracarotic Infusion q Hyperosolar Mannitol". No Shinkei Geka 1985 13(9):955-963. Abstract.
Miyagami et al. "The Effect on the Tumor Vessel Permeability by Hyperosmotic Blood Brain Barrier Disruption", No To Shinkei 1988 40(9):875-82 (Abstract).
Hodozuka et al., "Sequential Change of Capillary Permeability in the Rat Brain After Surgical Removal of a Experimental Brain Tumor", L. Neuroohcol. 1993 16(3):191-200. Abstract.
Koehler, P. J. Uses of Corticosteroids in Neuro-oncology. Anticancer Drugs 1995 61:19-33. Abstract.
Marh Jewicz et al. "Intracauotic Therapy with Etoposide and Cisplation for Malignant Brain Tumors", Cancer 1991 67:11 2844-9. Abstract.
Wiranocoska, M., "Blood Brian Barriers and Treatment of Central Nervous System Tumors, " J. Fla. Med. Assoc.,1992, 79 10:707-10. Abstract.
Yuan et al. "Vascular Permeability and Microcirulation of Gliomas and Mammary Carcinomas Transplanted in Rat and Mouse Cranial Windows". Cancer Res. 1994. 54(17) 4564-8. Abstract.
Blasberg et al., "Concurrent Measurements of Blood Flow and Transcapillary Transport in Avian Sarcoma-oiros induced experimental Brain Tumors: Implications for Chemotherapy". J. Pharmacol Exp. Ther. 1984 231 (3):724-35 Abstract.
Yamada et al., "Local Blood Flow and Capillary Permeability in the Experimental Meningeal Carcinomatosis," No To Shinkei, 1984 36(3):221-26. Abstract.
Groothius et al., "Regional Blood Flow and Blood to Tissue Transport in Five Brain Tumor Models, Implications for Chemotherapy: Prog Exp Tumor Res." 1984 27 132-53. Abstract.
Neuweh et al., "Inability of Dimethyl sulfoxide and 5-fluorouabcil to Open the Blood-Brain Barrier". Neurosurgery 1983 12(1):29-34.
Aizawa et al., "Measurement of Cerebral Blood Flow, Cerebrial Blood Volume, and Cerebral Capillary Permeability in Gluonia-Bearing Rats". Nerol. Med. Chir 1990 30 (2):113-18. Abstract.
Hiesiger et al. Opening the Blood-Brain and Blood tumor Barriers in Experimental Rat-Brain Tumors: the Effect of Intracaroted Hyper Osmolar Mannitol on Capillary Permeability and Blood Flow. Annual. Neurol. 1986 19 (1):50-9. Abstract.
Chan Christina Y.
Touzeau Phlynn
LandOfFree
Method for selective opening of abnormal brain tissue capillarie does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for selective opening of abnormal brain tissue capillarie, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for selective opening of abnormal brain tissue capillarie will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-222922