Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Transferases
Patent
1993-12-29
1996-11-05
Wax, Robert A.
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Transferases
424 943, 435 4, 435 6, 435 74, 435232, 514 46, A61K 3851, C12Q 168, C12N 988
Patent
active
055715109
ABSTRACT:
An improved method for chemotherapy of mammalian malignant cells which have an absolute requirement for methionine but lack methylthioadenosine phosphorylase (MTAse). The method comprises detection of MTAse negative cells in a mammal, administration of methionine .gamma.-lyase in sufficient amounts to reduce the volume of MTAse negative cells in the mammal, and co-administration of methylthioadenosine in amounts sufficient to ensure the continued availability of methionine to the mammal's non-malignant cells. Means for detection of MTAse negative cells are provided. Means for production and use of recombinant chemotherapeutic agents are also provided.
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Carson Dennis A.
Nobori Tsutomu
Prouty Rebecca
The Regents of the University of California
Wax Robert A.
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