Organic compounds -- part of the class 532-570 series – Organic compounds – Tetracyclo naphthacene configured ring system having at...
Patent
1994-11-16
1997-10-07
Cook, Rebecca
Organic compounds -- part of the class 532-570 series
Organic compounds
Tetracyclo naphthacene configured ring system having at...
A61K 3165
Patent
active
056750307
ABSTRACT:
The invention provides a method for selectively extracting a compound of formula I: ##STR1## wherein: R is hydrogen or --NR.sub.3 R.sub.4 ; and when R=--NR.sub.3 R.sub.4, R.sub.3 and R.sub.4 may be the same or different and are selected from hydrogen and straight or branched (C.sub.1 -C.sub.4)alkyl; R.sub.1 and R.sub.2 may be the same or different and are selected from straight or branched (C.sub.1 -C.sub.6)alkyl; from an aqueous mixture containing a compound of Formula I, its C-4 epimer and its oxidative degradation by-products by adding methylene at a concentration of 2-4 ml of methylene chloride per gram of compound of Formula I and at a pH between pH 6.5-8.0; and obtaining an extract containing methylene chloride, a compound of Formula I, and its C-4 epimer, said epimer being present in an amount of less than 3% of the amount of the compound of Formula I.
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Krishnan Lalitha
Krishnan Raghavan
Leese Richard A.
American Cyanamid Company
Cook Rebecca
Szatkowski T. S.
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