Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2006-03-29
2009-08-11
Bunner, Bridget E (Department: 1649)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007500, C435S334000, C436S501000
Reexamination Certificate
active
07572595
ABSTRACT:
The present invention relates to a method for searching myelin using gonadotropin-releasing hormone receptors (GnRH-R) as a biomarker, more precisely, a method for investigating the distribution of myelin by immunohistochemical staining using GnRH-R antibody, based on the fact that GnRH-R and myelin are observed in the same region. The method for searching myelin of the invention can contribute to the studies on demyelination related degenerative brain disease and the disclosure of functions of myelin and the relation of myelin and GnRH-R.
REFERENCES:
ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=399777; 8 pages: downloaded Sep. 27, 2008.
Peter et al., General and Comparative Endocrinol. 2003; 132: 399-408.
Millar et al., Journal of Endocrinol. 1999; 162: 117-126.
Jacobson, Jill D., “Gonadotropin-releasing hormone: potential role in autoimmunity,” International Immunopharmacology, 1:1077-1083 (2001).
Igaz et al., “Effects of Cytokines on Gonadotropin-Releasing Hormone (GnRH) Gene Expression in Primary Hypothalamic Neurons and in GnRH Neurons Immortalized Conditionally,” Endocrinology, 147(2):1037-1043 (2006).
Jacobson et al., “Gender-Specific Exacerbation of Murine Lupus by Gonadotropin-Releasing Hormone: Potential Role of Gαq/11,” Endocrinology, 140(8):3429-3437 (1999).
Huh Yong-Ho
Kwon Oh-Seung
Park Euna
Pyo Heesoo
Borgeest Christina
Bunner Bridget E
JHK Law
Kim Joseph Hyosuk
Korea Institute of Science and Technology
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