Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2006-01-17
2006-01-17
Murphy, Joseph (Department: 1646)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S320100, C435S325000, C435S069100
Reexamination Certificate
active
06986997
ABSTRACT:
A protein capable of transporting organic anions having amino acid sequences represented by SEQ ID NO: 1 or 2 or amino acid sequences derived therefrom by deletion, substitution or addition of one or more amino acid residues; and a gene coding for the protein. The protein and gene therefore are useful in vitro analysis of drug release and drug—drug interactions and development of method for screening drugs useful for preventing nephrotoxicity.
REFERENCES:
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Sweet DH, et al. Expression cloning and characterization of ROAT1. The basolateral organic anion tranpsorter in rat kidney. J Biol Chem. Nov. 28, 1997;272(48):30088-95.
Kanai N et al. Transient expression of oatp organic anion transporter in mammalian cells: identification of candidate substrates Am J Physiol Feb. 1996;270(2 Pt 2):F319-25.
Mickle JE et al. Genotype-phenotype relationships in cystic fibrosis. Med Clin North Am. May 2000;84(3):597-607.
Voet et al. Biochemistry. 1990. John Wiley & Sons, Inc. pp. 126-128 and 228-234.
Yan et al., Two-amino acid molecular switch in an epithelial morphogen that regulates binding to two distinct receptors. Science 290: 523-527, 2000.
Endou Hitoshi
Hosoyamada Makoto
Kanai Yoshikatsu
Sekine Takashi
Alexander John B.
Corless Peter F.
Edwards & Angell LLP
Endou Hitoshi
Fuji Bio Medix Co., Ltd.
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