Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving hydrolase
Reexamination Certificate
2005-04-05
2005-04-05
Prouty, Rebecca E. (Department: 1652)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving hydrolase
C435S019000, C435S190000, C435S007900, C435S007920, C435S007720, C435S325000, C435S252330, C435S196000, C536S023200
Reexamination Certificate
active
06875581
ABSTRACT:
A method for screening of modulators of calcineurin is provided, which uses the interaction between calcineurin and superoxide dismutase. Modulators of calcineurin are potential candidates for drugs, e.g. for immunosuppressive drugs. The forming of a complex comprising calcineurin and superoxide dismutase is monitorable in the presence of potential activators or inhibitors of calcineurin. Complex formation is performed within the cell by the use of appropriate expression vectors or in vitro using isolated proteins. Preferably, complex formation is monitored by fluorescence detection, especially by laser fluctuation correlation spectroscopy.
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Genopia Biomedical GmbH
Heiman Lee C.
Nath Gary M.
Nath & Associates PLLC
Prouty Rebecca E.
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