Method for screening MCH receptor antagonist/agonist

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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Details

C436S501000, C530S317000, C530S350000

Reexamination Certificate

active

10332082

ABSTRACT:
The present invention relates to a screening method for a compound or a salt thereof that alters the binding property of MCH or a salt thereof to SLT or a salt thereof, or a partial peptide thereof, an amide or an ester thereof, or a salt thereof, characterized by using MCH, a derivative or a salt thereof and SLT or a salt thereof, or a partial peptide thereof, an amide or an ester thereof, or a salt thereof. The screening method of the present invention is useful for screening an SLT agonist, which can be used as an agent for promoting appetite (eating), and an SLT antagonist, which can be used as a prophylactic and/or therapeutic agent for obesity.

REFERENCES:
patent: 6593108 (2003-07-01), Liu et al.
patent: WO99/28492 (1999-06-01), None
patent: WO 00/40725 (2000-07-01), None
patent: WO 00/49046 (2000-08-01), None
patent: WO 01/07606 (2001-02-01), None
patent: WO 01/36479 (2001-05-01), None
patent: WO 01/57070 (2001-08-01), None
patent: WO 01/70975 (2001-09-01), None
Lembo et al. “The receptor for the orexigenic peptide melanin-concentrating hormone is a G-protein-coupled receptor” Nature Cell Biol 1:267-271 (1999).
Bachner et al. “Identification of melanin concentrating hormone (MCH) as the natural ligand for the orphan somatostatin-like receptor 1 (SLC-1)” FEBS Letters 457:522-524 (1999).
Saito et al. “Molecular Characterization of the melanin-concentrating-hormone receptor” Nature 400: 265-269 (1999).
Chambers et al. “Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1” Nature 400: 261-265 (1999).
Shimomura et al. “Isolation and identification of Melanin-concentrating hormone as the endogenous ligand of the SLC-1 receptor” Biochemical and Biophysical Research Commun 261: 622-626 (1999).
MacDonald, D., et al., “Molecular Characterization of the Melanin-Concentrating Hormone/Receptor Complex: Identification of Critical Residues Involved in Binding and Activation”,Molecular Pharmacology, (2000), vol. 58, No. 1, pp. 217-225.
Hintermann, E., et al., “Synthesis and Receptor Binding Activity of Analogues and Fragments of Human Melanin-Concentrating Hormone (MCH)”,Database CA Online, Database Accession No. 132:203272, XP002346918, 1997.

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