Method for screening inhibitors of the enzyme which cleaves the

Details Method for screening inhibitors of the enzyme which cleaves the Method for screening inhibitors of the enzyme which cleaves the

1997-03-17

1999-10-19

Weber, Jon P.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving hydrolase

435219, 435220, 435221, C12Q 137, C12N 950, C12N 952, C12N 954

Patent

active

059687630

ABSTRACT:
The invention relates to an enzyme which cleaves surface proteins of gram-positive bacteria, to methods of detecting the enzyme, and methods of isolating the enzyme. In particular, the enzyme is isolated from a group A Streptococcus, and cleaves at the sequence LPXTGX (SEQ ID NO:1). A method for screening putative inhibitors of the enzyme which cleaves the anchor region of surface proteins from gram positive bacteria is also disclosed.

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