Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1996-06-05
1999-06-08
Loring, Susan A.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
5303879, 53038885, 5303893, 530381, C07K 1600, A61K 3514
Patent
active
059105763
ABSTRACT:
Method for screening for the presence of a genetic defect associated with thrombosis and/or poor anticoagulant response to activated protein C (APC). The method is directed at detecting one or more mutations at one or more of the cleavage and/or binding sites for APC of Factor V and/or Factor Va or at Factor VIII and/or Factor VIIIa at either nucleic acid or protein level or both.
REFERENCES:
patent: 5049491 (1991-09-01), Mann et al.
B. Dahlback et al., Thrombosis and Haemostasis, 65:6:658, Jun. 1991.
T. Koster et al., Lancet, 432:8886:1503-1506, Dec. 18, 1993.
N.L.L. Shen et al., The Journal of Immunology, 150:7:2992-3001, Apr. 1, 1993.
M. Kalafatis et al., Blood, 82:10S1:58A, Abstract 222, 1993.
J.S. Greengard et al., Lancet, 343:8909:1361-1362, May 28, 1994.
R.M. Bertina et al., Nature, 369:6475:64-67, May 5, 1994.
Mok et al., BioTechniques, 14(5):790-793 (1993).
AW Kogan et al., PCR Protocols, pp. 288-288, Ed. Innis et al., CA (1990).
Voorberg et al., Lancet, 343:1535-1536, Jun., 1994.
Zooler et al., Lancet, 343:1536-1538, Jun., 1994.
Tuddenham et al., Lancet, 343:1515-1516, Jun., 1994.
Beauchamp et al., Lancet, 344:694-695, Jun., 1994.
Odegaard, B. et al, J. Biol Chem, 262(23):11233-11238, Aug. 15, 1987.
Jenny, R. J. et al, PNAS, 84:4846-4850, Jul. 1987.
Kalafatis, M. et al, J. Biol Chem, 268(36):27246-27257, Dec. 25, 1993.
Baler, R. et al, Lancet, 344(8930):1162, Oct. 22, 1994.
Bertina Rogier Maria
Reitsma Pieter Hendrik
Blackstone William M.
Gormley Mary E.
Loring Susan A.
Rijks Universiteit Leiden
LandOfFree
Method for screening for the presence of a genetic defect associ does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for screening for the presence of a genetic defect associ, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for screening for the presence of a genetic defect associ will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1683924