Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1995-04-21
1999-11-23
Feisee, Lila
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 732, 435 29, 435 691, 514 2, 514154, 514 42, 514 23, 514183, G01N 3350, G01N 33566
Patent
active
059898321
ABSTRACT:
Methods are provided for screening for inhibitors of microbial efflux pumps including those which export antibiotics. The screening methods are based on the increase in the intracellular concentration of a compound, such as an antibiotic, when the bacterial cells are contacted with an efflux pump inhibitor. In addition, this invention provides pharmaceutical compositions containing such efflux pump inhibitors, and methods for treating microbial infections using those compositions.
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Chamberland Suzanne
Hecker Scott J.
Lee Ving J.
Trias Joaquim
Feisee Lila
Microcide Pharmaceuticals, Inc.
Pak Michael
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