Method for screening for Kawasaki disease

Details Method for screening for Kawasaki disease Method for screening for Kawasaki disease

1993-01-11

1994-02-15

Parr, Margaret

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 724, 435 91, C12Q 168, C12P 1934, G01N 3353

Patent

active

052866238

ABSTRACT:
The invention relates to screening of patients to determine the possible presence of Kawasaki Disease. The screening involves assaying for levels of V.beta.2 or V.beta.8.1 by immunoassay, or for the mRNA expressing either of these V.beta. elements. The polymerase chain reaction is one way the mRNA level can be determined. Once the levels in the patient are determined, they are compared to normal levels. An increase is indicative of possible Kawasaki Disease.

REFERENCES:
patent: 4886743 (1989-12-01), Hood et al.
Abe et al., "Selective expansion of T cells expressing T-Cell receptor variable regions VB2 and VB8 in Kawasaki disease", Proc. Natl. Acad. Sci. USA 89 4066-4070 (May 1992)-not prior art.
Yanagihara et al., "Acute Fibrille Mucocutaneous Lymph Node Syndrome", Am. J. Dis. Child 134: 603-613 (Jun., 1980).
Toyonga et al., "Genes of the T-Cell Antigen Receptor In Norman and Malignant Cells", Ann. Rev. Immunol. 5: 565-620 (1987).
White et al., "The VB-Sepcific Superantigen Staphlococal Entertoxin B:Stimulation of Mature T Cell and Clonal Deletion in Neonatal Mice", Cell 56: 27-35 (Jan. 13, 1989).
Kappler et al., "VB-Specific Stimulation of Human T Cells by Staphylococcal Toxins", Science 244: 811-813 (May 19, 1989).
Choi et al., "Interaction of Staphylococcus aureus toxin `superantigens` with human T cells", Proc. Natl. Acad. Sci. USA 86: 8941-8945 (Nov. 1989).
Leung et al., "Immunologic Aspects of Kawaski Disease Syndrome", J. Rheumatol (suppl 24: 15-17 (1990)).
Choi et al., "Selective Expansion of T Cells Expressing VB2 in Toxic Shock Shock Syndrome", J. Exp. Med. 172: 981-984 (Sep. 1990).
Choi et al., "A method for production of antibodies to human T-cell receptor B-chain variable regions", Proc. Natl. Acad. Sci. USA 88: 8537-8361 (Oct. 1991).
Kim et al. Reduction of lupus nephritis in MRL/lprmice by a bacterial superantigen treatment. J. Exp. Med (Dec. 1991) 174:1431-1437.
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