Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2007-10-31
2010-06-22
Bunner, Bridget E (Department: 1647)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S004000, C435S007200, C530S350000
Reexamination Certificate
active
07741057
ABSTRACT:
Methods and compositions for using the MHC class II invariant chain polypeptide, Ii (also known as CD74), as a receptor for macrophage migration inhibitory factor (MIF), are disclosed. These include methods and compositions for using this receptor, as well as agonists and antagonists of MIF which bind to this receptor, or which otherwise modulate the interaction of MIF with CD74 or the consequences of such interaction, in treatment of conditions characterized by locally or systemically altered MIF levels, particularly inflammatory conditions and cancer.
REFERENCES:
patent: 7514225 (2009-04-01), Gaeta et al.
patent: WO-9729635 (1997-08-01), None
Wells. J.A. Additivity of mutational effects in proteins. Biochemistry 29 (37): 8509-8517, 1990.
Ngo et al. Computational complexity, protein structure prediction, and the Levinthal paradox. The Protein Folding Problem and Tertiary Structure Prediction, pp. 492-495, 1994.
Leng et al. MIF signal transduction initiated by binding to CD74. J Exp Med 197(11):1467-1476, 2003.
Bucala Richard J.
Leng Lin
Metz Christine N.
Bunner Bridget E
Cytokine PharmaSciences, Inc.
Law Office of John K. Pike, PLLC
Pike John K.
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