Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1995-05-03
1999-03-09
Myers, Carla J.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
4351723, 4353201, 436 63, 536 2431, 536235, 935 9, 935 11, 935 23, 935 77, 935 78, C12Q 168, C12N 1511, C07H 2104
Patent
active
058798838
ABSTRACT:
Method for screening for risk of Alzheimer's disease involve assaying for a guanine to thymine substitution at position 1924 of the gene encoding the human amyloid precursor protein. Also described are transgenic mammals harboring an expressable gene sequence encoding human amyloid precursor protein having a phenyanine for valine amino acid substitution in the transmembrane domain of the amyloid precursor protein.
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Scheuner et al, Nature Medicine (Aug. 1996) 2: 864-870.
Games et al, Nature (Feb. 1995) 373: 523-527.
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Goate et al. Nature (1991) 349: 704-706.
Benson Merrill D.
Farlow Martin
Ghetti Bernardino
Murrell Jill
Indiana University Foundation
Myers Carla J.
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