Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving transferase
Reexamination Certificate
2007-12-18
2007-12-18
Gitomer, Ralph (Department: 1657)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving transferase
C435S008000
Reexamination Certificate
active
11144265
ABSTRACT:
The invention relates to methods for detecting a soluble guanylate cyclase whose heme iron is in the trivalent oxidation state, and to methods for finding chemical substances which stimulate the activity of a soluble guanylate cyclase when the heme iron of at least part of this soluble guanylate cyclase is oxidized to the trivalent state and also to diagnostic aids or kits for detecting a soluble guanylate cyclase with trivalent heme iron. Further, the invention relates methods for detecting a soluble guanylate cyclase lacking a heme group, and to methods for finding chemical substances which stimulate the activity of a soluble guanylate cyclase lacking a heme group.
REFERENCES:
patent: 5618665 (1997-04-01), Lurie et al.
patent: 6335334 (2002-01-01), Schindler et al.
patent: 6500631 (2002-12-01), Schindler et al.
patent: 6897232 (2005-05-01), Schindler et al.
patent: 6913898 (2005-07-01), Schindler et al.
patent: 2004/0186163 (2004-09-01), Bischoff et al.
patent: 2006/0147548 (2006-07-01), Motterlini et al.
patent: 198 37 015 (2000-02-01), None
patent: 876715 (1981-10-01), None
patent: WO 00/02851 (2000-01-01), None
Forester et al., A functional heme-binding site of soluble guanylyl cyclase requires intact N-termini of alpha one and Beta one subunits, Eur. J. Biochem, vol. 240, 1996, pp. 380-386.
G. Giuili et al., “Molecular clonging of the cDNAs coding for the two subunits of sclubie guanyiyl cyclase from human brain”, FEBS Letters, Volv. 304, No. 1, Jun. 1992, pp. 83-88.
Gupte et al., “NADPH and Heme Redox Modulate Pulmonary Artery Relaxation and Guanyiate Cyclase Activation by NO”, Am. J. Physiol. vol. 277, 1999, pp. L1124-L1132.
Humbert et al., “Preparation of Soluble Guanylyl Cyclase from Bovine Lung by Immunoaffinity Chromatography”, Methods in Enzymology, vol. 195, 1991, pp. 384-391.
Ignarro et al., “Selective Alterations in Responsiveness of Guanylate Cyclase to Activation by Nitroso Compounds During Enzyme Purification”, Biochemica et Biophysica Acta vol. 673, 1981, pp. 394-407.
L. Ignarro, “Regulation of Cytosolic Guanylyl Cyclase by Porphyrins and Metallaporphyrins”, Advances in Pharmacolocy, vol. 26, 1994, pp. 35-65.
Koesling et al., “Soluble Guanylyl Cyclase: Structure and Regulation”,Reviews of Physiology Biochemistry and Pharmacology, vol. 135, 1999, pp. 42-64.
Makino et al., “EPR Characterization of Axial Bond in Metal Center of Native and Cobalt-substituted Guanylate Cyclase”, J. of Biol. Chem., vol. 274, No. 12, Mar. 19, 1999, pp. 7714-7723.
Moro et al., cGMP mediates the vascular and platelet actions of nitric oxide: Confirmation using an inhibitor or the Soluble Guanylyl Cyclase, PNAS USA, vol. 93, Feb. 1996, pp. 1480-1485.
Nakane et al., “Molecular Cloning and Expression of cDNAs Coding for Soluble Guanylyl Cyclase from Rat Lung”, J. of Biol. Chem., vol. 265, No. 28, Oct. 5, 1990, pp. 16481-16486.
Olesen et al., “Characterization of NS 2028 as a Specific Inhibitor of Soluble Guanylyl Cyclase”, Br. J. of Pharamacology, vol. 123, 1998, pp. 299-309.
A. Schrammel, Characterization of 1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one as a Heme Site Inhibitor of Nitric Oxide Sensitive Guanlylyl Cyclase, Mol. Pharmacol. vol. 50, 1996, pp. 1-5.
J. Stone, “Spectral and Ligand Binding Properties of an Unusual Hemoprotein, The Ferric Form of Soluble Guanylate Cyclase”, Biochemistry, vol. 35, No. 10, 1996, pp. 3258-3262.
D.L. Vesely, “B complex vitamins activate rat Guanylate Cyclase and increase cyclic GMP levels”, Eur. J. of Clinical Investigation, vol. 15, 1985, pp. 258-262.
Yuen et al., “A New Form of Guanylyl Cyclase is Preferentially Expressed in Rat Kidney”, Biochemistry vol. 29, 1990, pp. 10872-10878.
Muelsch Alexander
Schindler Peter
Schindler Ursula
Strobel Hartmut
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