Surgery – Miscellaneous – Methods
Patent
1995-11-16
1998-03-10
Lacyk, John P.
Surgery
Miscellaneous
Methods
A61B 1900
Patent
active
057249954
ABSTRACT:
The method makes it possible to induce in an animal a paralysis, preferably paraplegia, which is total and reversible in a predetermined period of time, with the aid of a balloon which compresses the spinal marrow. The animal model is employed in a method for testing candidate factors with neuroprotective and/or neuroregenerative function, which are considered as positive if a reduction in the duration of the paralysis can be observed. Medicinal products, in particular neuroprotective and/or neuroregenerative medicinal products, comprising an active principle demonstrated by the test method.
REFERENCES:
Kobrine et al., "Effect of intravenous lidocaine on experimental spinal cord injury," Journal of Neurosurgery, vol. 60, pp.595-601, Mar. 1984.
Cole et al., "Halothane, Fentanyl/Nitrous Oxide, and Spinal Lidocaine Protect Against Spinal Cord Injury in the Rat," Anesthesiology, vol. 70, pp. 967-972, Jun. 1989.
Cole et al., "The Effect of Fentanyl Anesthesis and Intrathecal Naloxone of Neurologic Outcome Following Spinal Cord Injury in the Rat," Anesthesiology, vol. 71, pp. 426-430, Sep. 1989.
Pointillart et al., "Effects of Nimodipine on Posttraumatic Spinal Cord Ischemia in Baboons," Journal of Neurotrauma, vol. 10(2), pp. 201-213, 1993.
T. Ueno, et al; The Annals of Thoracic Surgery; Jul. 1, 1994; vol. 58; No. 1; "Spinal Cord Protection: Development of a Parapalegia-Preventive Solution"; pp. 116-120.
H.H. De Haan, et al; Pediatric Research; Sep. 1993; vol. 34; No. 3; "Possible Neuroprotective Properties of Flunarizine Infused After Asphyxia in Fetal Lambs Are Not Explained by Effects on Cerebral Blook Flow or Systemic Blood Pressure", pp. 379-384.
D. Martin, et al; Journal of Neuroscience Research; Aug.1992; vol. 32; No. 4; "Experimental Acute Traumatic Injury of the Adult Rat Spinal Cord by a Subdural Inflatable Balloon Methodology, Behavioral Analysis and Histopathology"; pp. 539-550.
M. Tarloy, et al; Archives of Neurology and Psychiatry; 1953; vol. 70; "Spinal Cord Compression Studies" pp. 813-819.
C.H. Tator, et al; The Canadian Journal of Surgery; 1973; vol. 16, "Acute Spinal Cord Injury in Primates Produced by An Inflatable Extradural Cuff" pp. 222-231.
D. Martin, et al; "Brain Research Bulletin"; 1993; vol. 30; Syngeneic Grafting of Adult Rate DRG-Derived Schwann Cells to the Injured Spinal Cord; pp. 507-514.
Lacyk John P.
Winakur Eric F.
LandOfFree
Method for screening factors on a paralysis model and method for does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for screening factors on a paralysis model and method for, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for screening factors on a paralysis model and method for will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-131570