Method for screening compounds against Flaviviruses by...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage

Reexamination Certificate

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C435S032000

Reexamination Certificate

active

11210183

ABSTRACT:
This invention provides a method for screening compounds againstFlavivirus. More specifically, this invention provides a method for screening compounds againstFlavivirusesby using a persistent virus-infected cell system, including (a) establishment of persistent virus-infected cell lines, (b) preparation of monoclonal antibody by using said persistent virus-infected cell lines, (c) incubation of tested compounds with said persistent virus-infected cell lines, (d) determination of the inhibition effect of tested compounds or vaccines onFlavivirusby sandwich ELISA using said monoclonal antibody.

REFERENCES:
patent: 2005/0048073 (2005-03-01), De Groot et al.
Houghton et al. “Prospects for a vaccine against the hepatitis C virus,” Nature, vol. 436, Aug. 18, 2005□□.
Liao et al., “Antiapoptotic but Not Antiviral Function of Human bcl-2 Asists Establishment of Japanese Encephalitis Virus Persistence in Cultured Cells,” Journal of Virology, vol. 72, No. 12, p. 9844-9854 (1998).
Pugachev et al., “New developments in flavivirus vaccines with special attention to yellow fever,” Curr. Opin. Infect. Dis. 18:387-394 (2005).
Rossi et al., “Adaptation of West Nile virus replicons to cells in culture and use of replicon-bearing cells to probe antiviral action,” Virology, 331, 457-470 (2005).
Shi et al. (“Strategies for the identification of inhibitors of West Nile virus and other flaviviruses, Curr Opin Investig Drugs,” 3(11): 1567-73 (2002)).

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