Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Reexamination Certificate
2008-05-27
2008-05-27
Mosher, Mary E. (Department: 1648)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
C435S032000
Reexamination Certificate
active
07378235
ABSTRACT:
This invention provides a method for screening compounds againstFlavivirus. More specifically, this invention provides a method for screening compounds againstFlavivirusesby using a persistent virus-infected cell system, including (a) establishment of persistent virus-infected cell lines, (b) preparation of monoclonal antibody by using said persistent virus-infected cell lines, (c) incubation of tested compounds with said persistent virus-infected cell lines, (d) determination of the inhibition effect of tested compounds or vaccines onFlavivirusby sandwich ELISA using said monoclonal antibody.
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Liao et al., “Antiapoptotic but Not Antiviral Function of Human bcl-2 Asists Establishment of Japanese Encephalitis Virus Persistence in Cultured Cells,” Journal of Virology, vol. 72, No. 12, p. 9844-9854 (1998).
Pugachev et al., “New developments in flavivirus vaccines with special attention to yellow fever,” Curr. Opin. Infect. Dis. 18:387-394 (2005).
Rossi et al., “Adaptation of West Nile virus replicons to cells in culture and use of replicon-bearing cells to probe antiviral action,” Virology, 331, 457-470 (2005).
Shi et al. (“Strategies for the identification of inhibitors of West Nile virus and other flaviviruses, Curr Opin Investig Drugs,” 3(11): 1567-73 (2002)).
Buddhist Tzu Chi General Hospital
Corless Peter F.
Edwards Angell Palmer & & Dodge LLP
Kim Dwight D.
Mosher Mary E.
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