Method for screening anti-tumor agents of the reticulo-endotheli

Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Attached to antibody or antibody fragment or immunoglobulin;...

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232303, 128659, A61K 4300, A61N 512

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active

043605109

ABSTRACT:
A procedure is disclosed for determining optimal doses, scheduling, routes of administration, the time for initiation, the magnitude and the duration of the anti-tumor effects, at various times following the administration to laboratory test animals such as rodents of doses of reticulo-endothelial stimulants by convenient anatomical routes. Following administration of the reticuloendothelial stimulant material the animals are challenged intravenously with radiolabelled tumor cells, and after 1 to 24 hours they are sacrificed, the lungs harvested and counted for radioactivity. The method allows for comparative studies on a number of agents and can be used as a screening assay as well as for the quality control of existing products.

REFERENCES:
Stiteler et al., J. Reticulo-Endothelial Soc., vol. 24, No. 6, Dec. 6, 1978, pp. 687-696.
Proctor et al., Cancer Treatment Reports, vol. 62, No. 11, Nov. 1978, pp. 1873-1880.

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