Chemistry: electrical and wave energy – Processes and products – Electrostatic field or electrical discharge
Patent
1993-01-21
1994-02-15
Tung, T.
Chemistry: electrical and wave energy
Processes and products
Electrostatic field or electrical discharge
356344, C25B 700
Patent
active
052863565
ABSTRACT:
A method for performing capillary electrophoresis with improved regularity of migration time of the analytes is disclosed. A capillary electrophoresis system includes a fused silica capillary, a high voltage power supply, electrolyte reservoirs at both ends of the capillary, means for injecting a sample, and a detector. After separation, analytes within the sample are identified by comparing their migration time with the migration time of internal or external standards. Since migration times are dependent on the concentration of the injected sample, identification of unknown analytes can often be difficult or subject to error without the use of such standards. These problems associated with concentration dependent migration time are substantially eliminated by using a combination of high voltage power supply running modes (i.e. constant current, constant voltage or constant power) during the course of the analysis. The control of the high voltage power supply can either be set before a run begins, or controlled directly using feedback from the separation in real time.
REFERENCES:
patent: 5015350 (1991-05-01), Wiktorowicz
Gebauer et al. "Sample self-stacking in zone electrophoresis. Theoretical description of the zone electrophoretic separation of minor compounds in the presence of bulk amounts of a sample component with high mobility and like charge." Journal of Chrom., 608(1992) 47-57.
CA 84(25): 176087g. A highly regulated, recording constant power, voltage, and current supply for electrophoresis and isoelectric focusing. 1976.
CA 84(3):14278t Accelerated liquid isolectric focusing using a direct current source that maintains constant power. 1976.
Fuchs Martin
Jones William R.
Merion Michael
Cook Paul J.
Delacroix-Muirheid Cybille
Karnakis Andrew T.
Millipore Corporation
Tung T.
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