Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1990-10-05
1992-02-25
Friedman, Stanley J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K 31415
Patent
active
050914049
ABSTRACT:
The use of cyclocreatine to preserve and/or restore the physiological functionality of muscle tissue subject to ischemia.
REFERENCES:
Chem. Abst.-107 (1987), 5298R.
Chem. Abst.-111 (1989), 106699j.
G. R. Griffiths and J. B. Walker-Accumulation of Analog of Phosphocreatine in Muscle of Chicks Fed 1-Carboxymethyl-2--iminoimidazolidine (Cyclocreatine), Journal of Biological Chemistry, vol. 251, pp. 2049-2054 (1976).
T. M. Annesley and J. B. Walker--Cyclocreatine Phosphate as a Substitute for Creatine Phosphate in Vertebrate Tissues. Energetic Considerations, Biochemical and Biophysical Research Communications, vol. 74, pp. 185-190 (1977).
J. B. Walker--Creatine: Biosynthesis, Regulation, and Function, Advan. Enzymol., vol. 50, pp. 177-242 (1979).
T. M. Annesley and J. B. Walker--Energy Metabolism of Skeletal Muscle Containing Cyclocreatine Phosphate--Delay in Onset of Rigor Mortis and Decreased Glycogenolysis in Response to Ischemia or Epinephrine, Journal of Biological Chemistry, vol. 255, pp. 3924-3930 (1980).
J. J. Roberts and J. B. Walker--Feeding a Creatine Analogue Delays ATP Depletion and Onset of Rigor in Ischemic Heart, J. Physiol., vol. 243, pp. H911-H916 (1982).
J. J. Roberts and J. B. Walker--Synthesis and Accumulation of an Extremely Stable High--Energy Phosphate Compound by Muscle, Heart, and Brain of Animals Fd the Creatine Analog, 1-Carboxyethyl-2-Iminoimidazolidine (Homocyclocreatine), Archives of Biochemistry and Biophysics, vol. 220, pp. 563-571 (1983).
Lary A. Robinson, M. D., Mark V. Braimbridge--Creatine phosphate: An Additive Myocardial Protective and Antiarrhythmic Agent in Cardioplegia, vol. 87, pp. 190-200 (1984).
D. M. Turner and J. B. Walker--Relative Abilities of Phosphagens with Different Thermodynmic or Kinetic Properties to Help Sustain ATP and Total Adenylate Pools in Heart During Ischemia, Archves of Biochemistry and Biophysics, vol. 238, pp. 642-651 (1985).
J. Roberts and J. B. Walker-Higher Homolog and N--Ethyl Analog of Creatine as Synthetic Phosphagen Precursors in Brain, Heart, and Muscle, Repressors of Liver Amidinotransferase, and Substrates for Creatine Catabolic Enzymes, Journal of Biological Chemistry, vol. 260, pp. 13502-13508 (1985).
M. L. Semenovsky, M.D., V. G. Sharov, M.D., G. M. Mogilevsky, M.D., A. V. Asmolovsky, M.D., L. A. Makhotina, Ph.D. and V. A. Saks, Ph.D., Protection of Ischemic Myocardium by Exogenous Phosphocreatine, vol. 94, pp. 762-769 (1987).
D. M. Turner and J. B. Walker--Enhanced Ability of Skeletal Muscle Containing Cyclocreatine Phosphate to Sustain ATP Levels During Ischemia Following B--Adrenergic Stimulation, Journal of Biological Chemistry, vol. 262, pp. 6605-6609 (1987).
James J. Morris, III, M.D., Gary L. Pellom, M.S., Charles E. Murphy, M.D., David R. Salter, M.D., Jacques P. Goldstein, M.D. and Andrew S. Wechsler, M.D., Quantification of the Conractile Response to Injury: Assessment of the Work-Length Relationship in the Intact Heart, vol. 76, No. 3, pp. 717-727 (Sep. 1987).
Mark D. Jacobstein, M.D., Facc. Thomas A. Gerken, Ph.D., Abdul M. Bhat, M.D., Pierre G. Carlier, M.D., Ph.D., Myocardial Protection During Ischemia by Prior Feeding with the Creatine Analog: Cyclocreatine, vol. 14, No. 1, pp. 246-251 (Jul. 1989).
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